The Red Devils moved up to 7th in the league table, now just 5 points behind league leaders Tottenham Hotspur, with a game in hand while Southampton stayed 5th.
United have now won eight consecutive top-flight away games for the first time in their history.
Southampton 2-3 Manchester United Team News:
United made two changes from the side that beat Istanbul Basaksehir in midweek – Matic and Greenwood started in place of Cavani and Anthony Martial.
Since his summer transfer from Ajax, this is the first time that Donny van de Beek has been named in a Premier League starting 11.
There was no Anthony Martial in the United matchday squad, due to illness. Paul Pogba and Scott McTominay were both unavailable due to injury issues, and Luke Shaw and Eric Bailly were missing too.
Hasenhuttl continued with the side that played against Wolves on Tuesday.
Southampton 2-3 Manchester United Analysis:
United could be seen making a bright start and seemed to be causing the hosts all sorts of problems. However, the momentum turned in the 23rd minute.
Ward-Prowse fired an inswinging corner to the near post, and Bednarek wriggled away from Rashford to shoot a header home from close range.
The hosts doubled their lead after 33 minutes when Ward-Prowse scored a fantastic free-kick, which saw De Gea’s knee strike the post in his attempt to save it.
De Gea was withdrawn with a suspected knee injury at half-time as Solskjaer made a double substitution. Dean Henderson came on alongside Cavani.
Cavani set up Fernandes to score on the hour mark to get United back in the game. Fernandes returned the favour within 14 minutes when his shot was turned into the back of the net by a Cavani header.
Manchester United dominated the latter stages, and Cavani struck again in stoppage time, stooping to head past Saints keeper Alex McCarthy.
Bruno Fernandes : 8
Class shone through. Played a key part in getting United back in the game with a level-headed finish for the opening goal. He also gave an assist.
Edinson Cavani (on for Greenwood ) : 9 [MOTM]
United benefited from his experience and turned the game on its head for the Red Devils with an assist and two goals.
James Ward-Prowse: 7
He was United’s tormentor in the first half, setting up the opener with a corner before floating a magnificent free-kick beyond David de Gea.
Manager Reaction to Cavani :
“He’s got all the attributes of a top-class footballer and a human being,”
“He’s had a great career, scored goals wherever, he’s meticulous with preparation and recovery, meal times, before and in the match. I was surprised he didn’t have his boots ready when the second-half started!”– Solskjaer on Cavani
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